Key Performance
More- Earnings Score: N/A
- Momentum Score: 35
- True Yield: N/A
- Financial Health Score: N/A
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Latest Research & News
Septerna's Chief People Officer Samira Shaikhly sold 11,798 shares worth approximately $355,000 on May 26, 2026, reducing her direct holdings by 93.7%. The sale was executed under a pre-arranged Rule 10b5-1 trading plan adopted in October 2025, indicating a non-discretionary transaction designed to avoid insider trading accusations. Despite the large insider sale, the company reported positive clinical trial progress and maintains strong cash reserves of $522.1 million, sufficient to fund operations into 2029.
07/05/2026, 9:35 AM • The Motley Fool
Is Septerna a Stock to Sell After an Insider Let Go of 15,000 Shares?
Septerna SVP Daniel D. Long exercised and sold 15,000 shares for ~$533,000 on June 22, 2026, reducing his direct holdings by 13.46%. The analyst suggests this appears to be routine income supplementation rather than a loss of confidence, as Long retains 96,412 shares and 36,000 unexercised options. Septerna, a clinical-stage biotech developing GPCR-targeted therapies, has shown positive phase 1 results for SEP-631 and maintains partnerships with Novo Nordisk.
06/29/2026, 11:05 PM • The Motley Fool
Septerna announced positive Phase 1 results for SEP-631, an oral MRGPRX2 negative allosteric modulator for treating mast cell-driven diseases. The drug demonstrated robust, dose-dependent inhibition of icatibant-induced skin wheal formation with complete inhibition at 10 mg once-daily, was well-tolerated with an adverse event profile comparable to placebo, and showed a pharmacokinetic profile supporting once-daily dosing. The company plans to initiate Phase 2b development in chronic spontaneous urticaria in the second half of 2026.
03/01/2026, 9:45 AM • GlobeNewswire
Septerna to Participate in 8th Annual Evercore Healthcare Conference
Septerna, a clinical-stage biotechnology company specializing in GPCR drug discovery, will participate in the 8th Annual Evercore Healthcare Conference on December 2, 2025, presenting via live webcast.
11/25/2025, 8:00 AM • GlobeNewswire
