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- 115.57%1-Year Change
- BiotechnologyIndustry
Protagonist Ther (PTGX)
Key Performance
More- Earnings Score: 13
- Momentum Score: 59
- True Yield: N/A
- Financial Health Score: 35
Latest Research & News
The polycythemia vera market is expected to expand significantly by 2036, growing at 8.9% CAGR from a 2025 valuation of approximately USD 2 billion. Nine major pharmaceutical companies are advancing next-generation therapies in various clinical development stages, with rusfertide from Protagonist Therapeutics and Takeda expected to be the first new entrant to market this year, potentially reshaping the treatment paradigm beyond current standard therapies like JAKAFI, BESREMi, and PEGASYS.
04/22/2026, 1:00 PM • GlobeNewswire
This Healthcare Stock Barely Flinches During Market Sell-Offs
Johnson & Johnson demonstrates resilience during market downturns, with shares falling less than 2% while the S&P 500 dropped over 7%. The healthcare giant maintains strong fundamentals including 63 consecutive years of dividend increases, $94.2 billion in 2025 revenue (up 6%), and 51 drug approvals last year. However, the stock faces headwinds from tens of thousands of talc-related lawsuits and Medicare drug price negotiations under the Inflation Reduction Act.
04/02/2026, 6:14 AM • The Motley Fool
The FDA approved Icotyde (icotrokinra), an oral IL-23 receptor antagonist for moderate-to-severe plaque psoriasis developed by Johnson & Johnson and Protagonist Therapeutics. The approval triggers a $50 million milestone payment to Protagonist with potential for up to $580 million in additional payments. AbbVie's stock fell 5.20% as analysts view Icotyde as competitive to AbbVie's Skyrizi, though both companies believe oral therapies could expand the overall psoriasis market.
03/19/2026, 8:25 AM • Benzinga
Protagonist Stock Up 120%, but One Fund Just Revealed a $170 Million Exit
Hedge fund BVF fully exited its position in Protagonist Therapeutics (PTGX), selling 2.56 million shares worth $170.12 million. Despite the stock rallying 120% over the past year, the fund's exit reflects a disciplined capital rotation strategy following the company's New Drug Application submission for rusfertide in polycythemia vera, marking a shift from clinical-stage risk to regulatory execution risk.
02/25/2026, 3:28 PM • The Motley Fool
Moody Aldrich Dumps Entire Stake in Chart Industries Worth $5.8 Million
Moody Aldrich Partners LLC completely sold its entire 35,228 share position in Chart Industries, valued at approximately $5.8 million, reducing its reportable assets to zero in Q3 2025.
10/23/2025, 2:25 PM • The Motley Fool
Moody Aldrich Liquidates Entire Stake in PLMR Worth $8.2 Million
Moody Aldrich Partners LLC completely sold its entire 53,211 share position in Palomar Holdings for an estimated $8.21 million during Q3 2025, reducing its stake to zero, likely as part of routine portfolio rebalancing.
10/21/2025, 5:03 PM • The Motley Fool
This 2.7%-Yielding Dividend King Remains One of the Healthiest Income Stocks You Can Buy
Johnson & Johnson demonstrated strong financial health in Q3, with 7% sales growth, $14.2 billion in free cash flow, and plans to separate its orthopedics business to focus on six priority growth areas. The company remains committed to dividend growth and oncology investments.
10/15/2025, 5:20 AM • The Motley Fool
Johnson & Johnson To Separate Orthopedics Business, Boosts Annual Sales Outlook
Johnson & Johnson reported strong Q3 2025 earnings, beating consensus estimates, and announced plans to separate its Orthopedics business into a standalone entity called DePuy Synthes within 18-24 months, targeting increased top-line growth and operating margins.
10/14/2025, 8:51 AM • Benzinga
FDA Adds New Warning For Johnson & Johnson's Cancer Cell Therapy
The FDA updated safety labeling for Johnson & Johnson's Carvykti cancer cell therapy, adding a warning about immune effector cell-associated enterocolitis, a serious complication with potential fatal outcomes. Despite the warning, regulators affirmed the therapy's benefits continue to outweigh its risks.
10/13/2025, 10:30 AM • Benzinga
Douglas Lane Adds $6 Million in J&J Stock Ahead of Earnings and Possible Biotech Deal
Douglas Lane & Associates increased its Johnson & Johnson stake by 34,948 shares, worth approximately $6 million in Q3, bringing total holdings to 667,373 shares valued at $123.7 million. The investment comes ahead of J&J's earnings report and potential biotech acquisition of Protagonist Therapeutics.
10/12/2025, 3:14 PM • The Motley Fool
Why Protagonist Therapeutics Stock Skyrocketed by Almost 30% Today
Clinical-stage biotech Protagonist Therapeutics saw its stock price jump 29.8% after The Wall Street Journal reported Johnson & Johnson is in discussions to acquire the company, based on their existing collaboration in drug development.
10/10/2025, 7:07 PM • The Motley Fool
Johnson & Johnson In Talks To Acquire Protagonist Therapeutics: Report
Johnson & Johnson is reportedly in discussions to acquire Protagonist Therapeutics, potentially strengthening its immunology and oncology portfolio by gaining access to rusfertide, an experimental therapy for rare blood cancer.
10/10/2025, 1:06 PM • Benzinga
Johnson & Johnson, Protagonist Study Shows Superior Skin Clearance In Psoriasis Trials
Johnson & Johnson and Protagonist Therapeutics released Phase 3 study results for icotrokinra, showing superior skin clearance in psoriasis treatment compared to placebo and competitor drugs, with sustained effectiveness and favorable safety profile.
09/17/2025, 3:15 PM • Benzinga
Protagonist (PTGX) Q2 Revenue Falls 26%
Protagonist Therapeutics reported Q2 2025 financial results, highlighting progress in clinical pipeline with rusfertide and icotrokinra drug candidates, while experiencing lower-than-expected revenue but maintaining strong cash reserves through 2028.
08/07/2025, 12:34 AM • The Motley Fool
Peers
Statistics
MoreInformation as of 06/22/2026
Company Profile
Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States. It develops Icotyde, a first-in-class investigational targeted oral peptide for the treatment of adults and pediatric patients 12 years of age and older with moderate-to-severe plaque psoriasis; and Rusfertide, a first-in-class investigational injectable mimetic of the natural hormone hepcidin in Phase 3 development for the treatment of the rare blood disorder polycythemia vera. The company is also developing PN-881, a potential best-in-class oral peptide IL-17 antagonist, for the treatment of immune-mediated skin diseases in Phase 1 clinical trials; PN-477 and PN-458, which are development candidates for the treatment of obesity; PN-8047, an orally administered hepcidin functional mimetic small molecule; L-4R alpha antagonist for the treatment of atopic dermatitis and moderate-to-severe asthma; and amylinR-based oral and subcutaneous mono- and poly-agonists for the treatment of obesity. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.
Key Executives
- Dinesh V. Patel
- Arturo Molina FACP
- Asif Ali
- Abha Bommireddi
- Venkat Thalladi
Current Ownership Distribution
- Institutions1.1B (76.58%)
- Mutual Funds332.5M (23.07%)
- Insiders5.0M (0.35%)
- Other0 (0.00%)