SYRE
Spyre Therap (SYRE)
NASDAQ
$91.65-$0.69 (-0.74%)
Price as of Oct 22, 2026 7:30 PM EDT
  • $8.6B
    Market Cap
  • 318.51%
    1-Year Change
  • Biotechnology
    Industry

Top Holders

Institutional
Mutual Funds
Holder
Ownership %
Shares Held
Change (Shares, %)
Report Date
FMR LLC
14.11%
13.0M
+1.2M (+9.56%)
Jun 30, 2026
BLACKROCK, INC.
7.05%
6.5M
+985,384 (+15.14%)
Jun 30, 2026
PERCEPTIVE ADVISORS LLC
4.68%
4.3M
+536,271 (+12.42%)
Jun 30, 2026
RTW INVESTMENTS, LP
4.61%
4.3M
+80,000 (+1.88%)
Jun 30, 2026
VANGUARD GROUP INC
4.37%
4.0M
+984,344 (+24.39%)
Dec 31, 2025
FAIRMOUNT FUNDS MANAGEMENT LLC
4.35%
4.0M
0 (0.00%)
Mar 31, 2026
PARADIGM BIOCAPITAL ADVISORS LP
4.16%
3.8M
+1.9M (+49.04%)
Jun 30, 2026

Current Ownership Distribution

  • Institutions598.0M (80.05%)
  • Mutual Funds143.6M (19.22%)
  • Insiders5.5M (0.73%)
  • Other0 (0.00%)

Insider Transactions

  • 0.73% (5.5M)
    Current InsiderOwnership (%, shares)
  • 0
    Number of InsiderBuying (last 12 months)
  • $0.00
    Amount of InsiderBuying (last 12 months)
  • 6
    Number of InsiderSelling (last 12 months)
  • $985.8M
    Amount of InsiderSelling (last 12 months)
Insider Name & Title
Type
Date
Transaction Value
Shares
Share Price
Shares After Transactions
Turtle Cameron
Chief Executive Officer
Sell
Oct 01, 2026
$53,484.00
600
$89.14
551,940
King-Jones Heidy
See Remarks
Exempt
Oct 01, 2026
$0.00
28,933
$0.00
482,478
Turtle Cameron
Chief Executive Officer
Sell
Oct 01, 2026
$241,738.30
2,683
$90.10
549,257
King-Jones Heidy
See Remarks
Exempt
Oct 01, 2026
$419,528.50
28,933
$14.50
31,778
Turtle Cameron
Chief Executive Officer
Sell
Oct 01, 2026
$241,350.62
2,638
$91.49
546,619
King-Jones Heidy
See Remarks
Sell
Oct 01, 2026
$35,696.00
400
$89.24
31,378
Turtle Cameron
Chief Executive Officer
Sell
Oct 01, 2026
$368,224.59
3,989
$92.31
542,630
King-Jones Heidy
See Remarks
Sell
Oct 01, 2026
$1.5M
16,605
$90.35
14,773
Turtle Cameron
Chief Executive Officer
Sell
Oct 01, 2026
$465,916.30
4,990
$93.37
537,640
King-Jones Heidy
See Remarks
Sell
Oct 01, 2026
$660,277.80
7,228
$91.35
7,545
Turtle Cameron
Chief Executive Officer
Sell
Oct 01, 2026
$9,391.00
100
$93.91
537,540
King-Jones Heidy
See Remarks
Sell
Oct 01, 2026
$194,670.00
2,100
$92.70
5,445
King-Jones Heidy
See Remarks
Sell
Oct 01, 2026
$242,996.00
2,600
$93.46
2,845
Burrows Scott L
Chief Financial Officer
Sell
Sep 02, 2026
$1.6M
18,232
$89.35
79,762
King-Jones Heidy
See Remarks
Exempt
Sep 02, 2026
$0.00
400
$0.00
511,411
King-Jones Heidy
See Remarks
Exempt
Sep 02, 2026
$5,800.00
400
$14.50
3,245
King-Jones Heidy
See Remarks
Sell
Sep 02, 2026
$36,000.00
400
$90.00
2,845
Burrows Scott L
Chief Financial Officer
Exempt
Sep 01, 2026
$0.00
7,500
$0.00
337,357
King-Jones Heidy
See Remarks
Exempt
Sep 01, 2026
$0.00
27,999
$0.00
511,811
Burrows Scott L
Chief Financial Officer
Exempt
Sep 01, 2026
$108,750.00
7,500
$14.50
105,494
King-Jones Heidy
See Remarks
Exempt
Sep 01, 2026
$405,985.50
27,999
$14.50
30,844
Burrows Scott L
Chief Financial Officer
Sell
Sep 01, 2026
$77,625.00
900
$86.25
104,594
King-Jones Heidy
See Remarks
Sell
Sep 01, 2026
$418,608.00
4,845
$86.40
25,999
Burrows Scott L
Chief Financial Officer
Sell
Sep 01, 2026
$381,890.24
4,384
$87.11
100,210
King-Jones Heidy
See Remarks
Sell
Sep 01, 2026
$1.4M
16,548
$87.20
9,451
Burrows Scott L
Chief Financial Officer
Sell
Sep 01, 2026
$177,468.48
2,016
$88.03
98,194
King-Jones Heidy
See Remarks
Sell
Sep 01, 2026
$547,183.02
6,206
$88.17
3,245
Burrows Scott L
Chief Financial Officer
Sell
Sep 01, 2026
$17,808.00
200
$89.04
97,994
King-Jones Heidy
See Remarks
Sell
Sep 01, 2026
$35,752.00
400
$89.38
2,845
Burrows Scott L
Chief Financial Officer
Exempt
Aug 03, 2026
$0.00
7,500
$0.00
344,857