SYRE
Spyre Therap (SYRE)
NASDAQ
$90.68+$0.08 (+0.08%)
Price as of Sep 11, 2026 7:30 PM EDT
  • $8.0B
    Market Cap
  • 478.91%
    1-Year Change
  • Biotechnology
    Industry

Top Holders

Institutional
Mutual Funds
Holder
Ownership %
Shares Held
Change (Shares, %)
Report Date
FMR LLC
15.00%
13.0M
+1.2M (+9.56%)
Jun 30, 2026
BLACKROCK, INC.
7.49%
6.5M
+985,384 (+15.14%)
Jun 30, 2026
PERCEPTIVE ADVISORS LLC
4.97%
4.3M
+536,271 (+12.42%)
Jun 30, 2026
RTW INVESTMENTS, LP
4.90%
4.3M
+80,000 (+1.88%)
Jun 30, 2026
VANGUARD GROUP INC
4.65%
4.0M
+984,344 (+24.39%)
Dec 31, 2025
FAIRMOUNT FUNDS MANAGEMENT LLC
4.63%
4.0M
0 (0.00%)
Mar 31, 2026
PARADIGM BIOCAPITAL ADVISORS LP
4.42%
3.8M
+1.9M (+49.04%)
Jun 30, 2026

Current Ownership Distribution

  • Institutions598.0M (81.33%)
  • Mutual Funds131.8M (17.92%)
  • Insiders5.5M (0.75%)
  • Other0 (0.00%)

Insider Transactions

  • 0.75% (5.5M)
    Current InsiderOwnership (%, shares)
  • 0
    Number of InsiderBuying (last 12 months)
  • $0.00
    Amount of InsiderBuying (last 12 months)
  • 6
    Number of InsiderSelling (last 12 months)
  • $684.5M
    Amount of InsiderSelling (last 12 months)
Insider Name & Title
Type
Date
Transaction Value
Shares
Share Price
Shares After Transactions
Burrows Scott L
Chief Financial Officer
Sell
Sep 02, 2026
$1.6M
18,232
$89.35
79,762
King-Jones Heidy
See Remarks
Exempt
Sep 02, 2026
$0.00
400
$0.00
511,411
King-Jones Heidy
See Remarks
Exempt
Sep 02, 2026
$5,800.00
400
$14.50
3,245
King-Jones Heidy
See Remarks
Sell
Sep 02, 2026
$36,000.00
400
$90.00
2,845
Burrows Scott L
Chief Financial Officer
Exempt
Sep 01, 2026
$0.00
7,500
$0.00
337,357
King-Jones Heidy
See Remarks
Exempt
Sep 01, 2026
$0.00
27,999
$0.00
511,811
Burrows Scott L
Chief Financial Officer
Exempt
Sep 01, 2026
$108,750.00
7,500
$14.50
105,494
King-Jones Heidy
See Remarks
Exempt
Sep 01, 2026
$405,985.50
27,999
$14.50
30,844
Burrows Scott L
Chief Financial Officer
Sell
Sep 01, 2026
$77,625.00
900
$86.25
104,594
King-Jones Heidy
See Remarks
Sell
Sep 01, 2026
$418,608.00
4,845
$86.40
25,999
Burrows Scott L
Chief Financial Officer
Sell
Sep 01, 2026
$381,890.24
4,384
$87.11
100,210
King-Jones Heidy
See Remarks
Sell
Sep 01, 2026
$1.4M
16,548
$87.20
9,451
Burrows Scott L
Chief Financial Officer
Sell
Sep 01, 2026
$177,468.48
2,016
$88.03
98,194
King-Jones Heidy
See Remarks
Sell
Sep 01, 2026
$547,183.02
6,206
$88.17
3,245
Burrows Scott L
Chief Financial Officer
Sell
Sep 01, 2026
$17,808.00
200
$89.04
97,994
King-Jones Heidy
See Remarks
Sell
Sep 01, 2026
$35,752.00
400
$89.38
2,845
Burrows Scott L
Chief Financial Officer
Exempt
Aug 03, 2026
$0.00
7,500
$0.00
344,857
Burrows Scott L
Chief Financial Officer
Exempt
Aug 03, 2026
$108,750.00
7,500
$14.50
105,494
Burrows Scott L
Chief Financial Officer
Sell
Aug 03, 2026
$485,571.00
5,100
$95.21
100,394
Burrows Scott L
Chief Financial Officer
Sell
Aug 03, 2026
$221,490.00
2,300
$96.30
98,094
Burrows Scott L
Chief Financial Officer
Sell
Aug 03, 2026
$9,710.00
100
$97.10
97,994
Burrows Scott L
Chief Financial Officer
Exempt
Jul 01, 2026
$0.00
7,500
$0.00
352,357
Burrows Scott L
Chief Financial Officer
Exempt
Jul 01, 2026
$108,750.00
7,500
$14.50
105,494
Burrows Scott L
Chief Financial Officer
Sell
Jul 01, 2026
$505,601.25
5,775
$87.55
99,719
Burrows Scott L
Chief Financial Officer
Sell
Jul 01, 2026
$152,438.25
1,725
$88.37
97,994
Burrows Scott L
Chief Financial Officer
Exempt
Jun 25, 2026
$0.00
15,000
$0.00
359,857
Burrows Scott L
Chief Financial Officer
Exempt
Jun 25, 2026
$217,500.00
15,000
$14.50
112,994
Burrows Scott L
Chief Financial Officer
Sell
Jun 25, 2026
$435,600.00
5,000
$87.12
107,994
Burrows Scott L
Chief Financial Officer
Sell
Jun 25, 2026
$871,400.00
10,000
$87.14
97,994
Fairmount Funds Management LLC
Conversion
Jun 23, 2026
$0.00
16,667
$0.00
0