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Spyre Therap (SYRE)
NASDAQ
$95.26+$1.53 (+1.64%)
Price as of Jul 14, 2026 5:38 AM EDT- $8.1BMarket Cap
- 471.18%1-Year Change
- BiotechnologyIndustry
Spyre Therap (SYRE)
$95.26+$1.53 (+1.64%)
Top Holders
Institutional
Mutual Funds
Holder | Ownership %
| Shares Held | Change (Shares, %) | Report Date |
|---|---|---|---|---|
FMR LLC | 19.50% | 11.8M | +142,205 (+1.21%) | Mar 31, 2026 |
BLACKROCK, INC. | 9.14% | 5.5M | -880 (-0.02%) | Mar 31, 2026 |
RTW INVESTMENTS, LP | 6.91% | 4.2M | 0 (0.00%) | Mar 31, 2026 |
VANGUARD GROUP INC | 6.68% | 4.0M | +984,344 (+24.39%) | Dec 31, 2025 |
FAIRMOUNT FUNDS MANAGEMENT LLC | 6.65% | 4.0M | 0 (0.00%) | Mar 31, 2026 |
PERCEPTIVE ADVISORS LLC | 6.26% | 3.8M | +714,000 (+18.87%) | Mar 31, 2026 |
VR ADVISER, LLC | 6.10% | 3.7M | 0 (0.00%) | Mar 31, 2026 |
Holder | Ownership %
| Shares Held | Change (Shares, %) | Report Date |
|---|---|---|---|---|
FIDELITY MT VERNON STREET TRUST | 5.85% | 3.5M | -22,918 (-0.65%) | Feb 28, 2026 |
VANGUARD INDEX FUNDS | 4.93% | 3.0M | +101,392 (+3.40%) | Mar 31, 2026 |
SMALLCAP WORLD FUND INC | 3.99% | 2.4M | -1.3M (-53.05%) | Mar 31, 2026 |
FIDELITY SECURITIES FUND | 2.82% | 1.7M | -51,200 (-3.01%) | Apr 30, 2026 |
FIDELITY SELECT PORTFOLIOS | 2.22% | 1.3M | 0 (0.00%) | Apr 30, 2026 |
FIDELITY ADVISOR SERIES VII | 2.09% | 1.3M | +42,079 (+3.33%) | Apr 30, 2026 |
SPDR SERIES TRUST | 1.77% | 1.1M | 0 (0.00%) | Apr 30, 2026 |
Current Ownership Distribution
- Institutions500.3M (81.83%)
- Mutual Funds105.5M (17.25%)
- Insiders5.6M (0.92%)
- Other0 (0.00%)
Insider Transactions
- 0.92% (5.6M)Current InsiderOwnership (%, shares)
- 0Number of InsiderBuying (last 12 months)
- $0.00Amount of InsiderBuying (last 12 months)
- 5Number of InsiderSelling (last 12 months)
- $614.8MAmount of InsiderSelling (last 12 months)
Insider Name & Title | Type | Date
| Transaction Value | Shares | Share Price | Shares After Transactions |
|---|---|---|---|---|---|---|
Burrows Scott L Chief Financial Officer | Exempt | Jul 01, 2026 | $0.00 | 7,500 | $0.00 | 352,357 |
Burrows Scott L Chief Financial Officer | Exempt | Jul 01, 2026 | $108,750.00 | 7,500 | $14.50 | 105,494 |
Burrows Scott L Chief Financial Officer | Sell | Jul 01, 2026 | $505,601.25 | 5,775 | $87.55 | 99,719 |
Burrows Scott L Chief Financial Officer | Sell | Jul 01, 2026 | $152,438.25 | 1,725 | $88.37 | 97,994 |
Burrows Scott L Chief Financial Officer | Exempt | Jun 25, 2026 | $0.00 | 15,000 | $0.00 | 359,857 |
Burrows Scott L Chief Financial Officer | Exempt | Jun 25, 2026 | $217,500.00 | 15,000 | $14.50 | 112,994 |
Burrows Scott L Chief Financial Officer | Sell | Jun 25, 2026 | $435,600.00 | 5,000 | $87.12 | 107,994 |
Burrows Scott L Chief Financial Officer | Sell | Jun 25, 2026 | $871,400.00 | 10,000 | $87.14 | 97,994 |
Fairmount Funds Management LLC | Conversion | Jun 23, 2026 | $0.00 | 16,667 | $0.00 | 0 |
Fairmount Funds Management LLC | Conversion | Jun 23, 2026 | $0.00 | 666,680 | $0.00 | 4.7M |
Fairmount Funds Management LLC | Sell | Jun 23, 2026 | $399.7M | 4.7M | $85.31 | 0 |
HENDERSON MICHAEL THOMAS | Sell | Jun 22, 2026 | $2.0M | 20,000 | $100.00 | 68,606 |
Turtle Cameron Chief Executive Officer | Sell | Apr 01, 2026 | $607,324.80 | 12,344 | $49.20 | 630,196 |
Sloan Sheldon Chief Medical Officer | Exempt | Apr 01, 2026 | $0.00 | 7,958 | $0.00 | 87,542 |
Turtle Cameron Chief Executive Officer | Sell | Apr 01, 2026 | $132,587.52 | 2,656 | $49.92 | 627,540 |
Sloan Sheldon Chief Medical Officer | Exempt | Apr 01, 2026 | $172,370.28 | 7,958 | $21.66 | 7,958 |
Sloan Sheldon Chief Medical Officer | Sell | Apr 01, 2026 | $397,900.00 | 7,958 | $50.00 | 0 |
Burrows Scott L Chief Financial Officer | Exempt | Mar 03, 2026 | $0.00 | 2,500 | $0.00 | 402,357 |
Burrows Scott L Chief Financial Officer | Exempt | Mar 03, 2026 | $36,250.00 | 2,500 | $14.50 | 100,494 |
Burrows Scott L Chief Financial Officer | Sell | Mar 03, 2026 | $93,288.00 | 2,300 | $40.56 | 98,194 |
Burrows Scott L Chief Financial Officer | Sell | Mar 03, 2026 | $8,332.00 | 200 | $41.66 | 97,994 |
Turtle Cameron Chief Executive Officer | Sell | Feb 02, 2026 | $30,451.74 | 957 | $31.82 | 671,583 |
Turtle Cameron Chief Executive Officer | Sell | Feb 02, 2026 | $461,593.41 | 14,043 | $32.87 | 657,540 |
Sloan Sheldon Chief Medical Officer | Award | Jan 09, 2026 | $0.00 | 140,000 | $0.00 | 140,000 |
Burrows Scott L Chief Financial Officer | Award | Jan 09, 2026 | $0.00 | 140,000 | $0.00 | 140,000 |
Turtle Cameron Chief Executive Officer | Award | Jan 09, 2026 | $0.00 | 528,000 | $0.00 | 528,000 |
King-Jones Heidy See Remarks | Award | Jan 09, 2026 | $0.00 | 140,000 | $0.00 | 140,000 |
Turtle Cameron Chief Executive Officer | Sell | Jan 02, 2026 | $387,243.23 | 12,709 | $30.47 | 674,198 |
Turtle Cameron Chief Executive Officer | Sell | Jan 02, 2026 | $69,651.89 | 2,191 | $31.79 | 672,007 |
Turtle Cameron Chief Executive Officer | Sell | Jan 02, 2026 | $3,239.00 | 100 | $32.39 | 671,907 |