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Spyre Therap (SYRE)
NASDAQ
$106.00-$0.49 (-0.46%)
Price as of Aug 21, 2026 7:37 PM EDT- $9.4BMarket Cap
- 512.72%1-Year Change
- BiotechnologyIndustry
Spyre Therap (SYRE)
$106.00-$0.49 (-0.46%)
Top Holders
Institutional
Mutual Funds
Holder | Ownership %
| Shares Held | Change (Shares, %) | Report Date |
|---|---|---|---|---|
FMR LLC | 15.00% | 13.0M | +1.2M (+9.56%) | Jun 30, 2026 |
BLACKROCK, INC. | 7.49% | 6.5M | +985,384 (+15.14%) | Jun 30, 2026 |
PERCEPTIVE ADVISORS LLC | 4.97% | 4.3M | +536,271 (+12.42%) | Jun 30, 2026 |
RTW INVESTMENTS, LP | 4.90% | 4.3M | +80,000 (+1.88%) | Jun 30, 2026 |
VANGUARD GROUP INC | 4.65% | 4.0M | +984,344 (+24.39%) | Dec 31, 2025 |
FAIRMOUNT FUNDS MANAGEMENT LLC | 4.63% | 4.0M | 0 (0.00%) | Mar 31, 2026 |
PARADIGM BIOCAPITAL ADVISORS LP | 4.42% | 3.8M | +1.9M (+49.04%) | Jun 30, 2026 |
Holder | Ownership %
| Shares Held | Change (Shares, %) | Report Date |
|---|---|---|---|---|
FIDELITY MT VERNON STREET TRUST | 4.60% | 4.0M | +465,647 (+11.65%) | May 31, 2026 |
VANGUARD INDEX FUNDS | 3.43% | 3.0M | +101,392 (+3.40%) | Mar 31, 2026 |
SMALLCAP WORLD FUND INC | 2.78% | 2.4M | -1.3M (-53.05%) | Mar 31, 2026 |
FIDELITY SECURITIES FUND | 1.96% | 1.7M | -51,200 (-3.01%) | Apr 30, 2026 |
FIDELITY ADVISOR SERIES VII | 1.45% | 1.3M | +42,079 (+3.33%) | Apr 30, 2026 |
FIDELITY SELECT PORTFOLIOS | 1.34% | 1.2M | -178,800 (-15.37%) | May 31, 2026 |
SPDR SERIES TRUST | 1.23% | 1.1M | 0 (0.00%) | Apr 30, 2026 |
Current Ownership Distribution
- Institutions597.9M (83.34%)
- Mutual Funds113.9M (15.88%)
- Insiders5.6M (0.78%)
- Other0 (0.00%)
Insider Transactions
- 0.78% (5.6M)Current InsiderOwnership (%, shares)
- 0Number of InsiderBuying (last 12 months)
- $0.00Amount of InsiderBuying (last 12 months)
- 5Number of InsiderSelling (last 12 months)
- $642.6MAmount of InsiderSelling (last 12 months)
Insider Name & Title | Type | Date
| Transaction Value | Shares | Share Price | Shares After Transactions |
|---|---|---|---|---|---|---|
Burrows Scott L Chief Financial Officer | Exempt | Aug 03, 2026 | $0.00 | 7,500 | $0.00 | 344,857 |
Burrows Scott L Chief Financial Officer | Exempt | Aug 03, 2026 | $108,750.00 | 7,500 | $14.50 | 105,494 |
Burrows Scott L Chief Financial Officer | Sell | Aug 03, 2026 | $485,571.00 | 5,100 | $95.21 | 100,394 |
Burrows Scott L Chief Financial Officer | Sell | Aug 03, 2026 | $221,490.00 | 2,300 | $96.30 | 98,094 |
Burrows Scott L Chief Financial Officer | Sell | Aug 03, 2026 | $9,710.00 | 100 | $97.10 | 97,994 |
Burrows Scott L Chief Financial Officer | Exempt | Jul 01, 2026 | $0.00 | 7,500 | $0.00 | 352,357 |
Burrows Scott L Chief Financial Officer | Exempt | Jul 01, 2026 | $108,750.00 | 7,500 | $14.50 | 105,494 |
Burrows Scott L Chief Financial Officer | Sell | Jul 01, 2026 | $505,601.25 | 5,775 | $87.55 | 99,719 |
Burrows Scott L Chief Financial Officer | Sell | Jul 01, 2026 | $152,438.25 | 1,725 | $88.37 | 97,994 |
Burrows Scott L Chief Financial Officer | Exempt | Jun 25, 2026 | $0.00 | 15,000 | $0.00 | 359,857 |
Burrows Scott L Chief Financial Officer | Exempt | Jun 25, 2026 | $217,500.00 | 15,000 | $14.50 | 112,994 |
Burrows Scott L Chief Financial Officer | Sell | Jun 25, 2026 | $435,600.00 | 5,000 | $87.12 | 107,994 |
Burrows Scott L Chief Financial Officer | Sell | Jun 25, 2026 | $871,400.00 | 10,000 | $87.14 | 97,994 |
Fairmount Funds Management LLC | Conversion | Jun 23, 2026 | $0.00 | 16,667 | $0.00 | 0 |
Fairmount Funds Management LLC | Conversion | Jun 23, 2026 | $0.00 | 666,680 | $0.00 | 4.7M |
Fairmount Funds Management LLC | Sell | Jun 23, 2026 | $399.7M | 4.7M | $85.31 | 0 |
HENDERSON MICHAEL THOMAS | Sell | Jun 22, 2026 | $2.0M | 20,000 | $100.00 | 68,606 |
Turtle Cameron Chief Executive Officer | Sell | Apr 01, 2026 | $607,324.80 | 12,344 | $49.20 | 630,196 |
Sloan Sheldon Chief Medical Officer | Exempt | Apr 01, 2026 | $0.00 | 7,958 | $0.00 | 87,542 |
Turtle Cameron Chief Executive Officer | Sell | Apr 01, 2026 | $132,587.52 | 2,656 | $49.92 | 627,540 |
Sloan Sheldon Chief Medical Officer | Exempt | Apr 01, 2026 | $172,370.28 | 7,958 | $21.66 | 7,958 |
Sloan Sheldon Chief Medical Officer | Sell | Apr 01, 2026 | $397,900.00 | 7,958 | $50.00 | 0 |
Burrows Scott L Chief Financial Officer | Exempt | Mar 03, 2026 | $0.00 | 2,500 | $0.00 | 402,357 |
Burrows Scott L Chief Financial Officer | Exempt | Mar 03, 2026 | $36,250.00 | 2,500 | $14.50 | 100,494 |
Burrows Scott L Chief Financial Officer | Sell | Mar 03, 2026 | $93,288.00 | 2,300 | $40.56 | 98,194 |
Burrows Scott L Chief Financial Officer | Sell | Mar 03, 2026 | $8,332.00 | 200 | $41.66 | 97,994 |
Turtle Cameron Chief Executive Officer | Sell | Feb 02, 2026 | $30,451.74 | 957 | $31.82 | 671,583 |
Turtle Cameron Chief Executive Officer | Sell | Feb 02, 2026 | $461,593.41 | 14,043 | $32.87 | 657,540 |
Sloan Sheldon Chief Medical Officer | Award | Jan 09, 2026 | $0.00 | 140,000 | $0.00 | 140,000 |
Burrows Scott L Chief Financial Officer | Award | Jan 09, 2026 | $0.00 | 140,000 | $0.00 | 140,000 |