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UPSTREAM BIO (UPB)
NASDAQ
$2.92-$0.07 (-2.34%)
Price as of Oct 22, 2026 7:30 PM EDT- $153.4MMarket Cap
- -87.36%1-Year Change
- BiotechnologyIndustry
UPSTREAM BIO (UPB)
$2.92-$0.07 (-2.34%)
Top Holders
Institutional
Mutual Funds
Holder | Ownership %
| Shares Held | Change (Shares, %) | Report Date |
|---|---|---|---|---|
FMR LLC | 14.90% | 8.2M | +61,334 (+0.75%) | Jun 30, 2026 |
ORBIMED ADVISORS LLC | 10.40% | 5.7M | 0 (0.00%) | Jun 30, 2026 |
NORGES BANK | 6.88% | 3.8M | +3.8M (+100.00%) | Jun 30, 2026 |
BLACKROCK, INC. | 6.85% | 3.8M | +382,669 (+10.20%) | Jun 30, 2026 |
DECHENG CAPITAL LLC | 4.98% | 2.7M | 0 (0.00%) | Jun 30, 2026 |
ENAVATE SCIENCES GP, LLC | 4.49% | 2.5M | 0 (0.00%) | Jun 30, 2026 |
VANGUARD GROUP INC | 4.36% | 2.4M | -54,112 (-2.27%) | Dec 31, 2025 |
Holder | Ownership %
| Shares Held | Change (Shares, %) | Report Date |
|---|---|---|---|---|
FIDELITY SECURITIES FUND | 5.53% | 3.0M | 0 (0.00%) | Jul 31, 2026 |
VANGUARD INDEX FUNDS | 3.34% | 1.8M | +3,412 (+0.19%) | Jun 30, 2026 |
FIDELITY CAPITAL TRUST | 2.41% | 1.3M | 0 (0.00%) | Jul 31, 2026 |
FIDELITY ADVISOR SERIES VII | 1.99% | 1.1M | 0 (0.00%) | Jul 31, 2026 |
FIDELITY CONCORD STREET TRUST | 0.80% | 440,356 | +111,146 (+25.24%) | Jul 31, 2026 |
FIDELITY SALEM STREET TRUST | 0.71% | 386,524 | +337,182 (+87.23%) | Jul 31, 2026 |
VANGUARD HORIZON FUNDS | 0.43% | 234,635 | +137,333 (+58.53%) | Jun 30, 2026 |
Current Ownership Distribution
- Institutions281.2M (87.47%)
- Mutual Funds40.0M (12.45%)
- Insiders270,001 (0.08%)
- Other0 (0.00%)
Insider Transactions
- 0.08% (270,001)Current InsiderOwnership (%, shares)
- 0Number of InsiderBuying (last 12 months)
- $0.00Amount of InsiderBuying (last 12 months)
- 5Number of InsiderSelling (last 12 months)
- $3.0MAmount of InsiderSelling (last 12 months)
Insider Name & Title | Type | Date
| Transaction Value | Shares | Share Price | Shares After Transactions |
|---|---|---|---|---|---|---|
Deykin Aaron Chief Medical Officer | Sell | Sep 16, 2026 | $4,913.55 | 895 | $5.49 | 32,302 |
Houghton Adam Chief Business Officer | Sell | Sep 16, 2026 | $3,843.00 | 700 | $5.49 | 22,901 |
Sutherland Everett Rand Chief Executive Officer | Sell | Sep 16, 2026 | $11,501.55 | 2,095 | $5.49 | 68,717 |
Sutherland Everett Rand Chief Executive Officer | Sell | Jun 16, 2026 | $12,779.50 | 2,095 | $6.10 | 70,812 |
Ambrose Allison General Counsel | Sell | Jun 16, 2026 | $2,909.70 | 477 | $6.10 | 16,048 |
Houghton Adam Chief Business Officer | Sell | Jun 16, 2026 | $4,270.00 | 700 | $6.10 | 23,601 |
Deykin Aaron Chief Medical Officer | Sell | Jun 16, 2026 | $5,459.50 | 895 | $6.10 | 33,197 |
GRAY MICHAEL CFO and COO | Sell | Jun 16, 2026 | $5,203.30 | 853 | $6.10 | 28,795 |
Renaud Ronald C JR | Award | Jun 09, 2026 | $0.00 | 17,096 | $0.00 | 17,096 |
Beckman Daniella | Award | Jun 09, 2026 | $0.00 | 17,096 | $0.00 | 17,096 |
Fleming Harold Edward | Award | Jun 09, 2026 | $0.00 | 17,096 | $0.00 | 17,096 |
Ruddy Marcella K. | Award | Jun 09, 2026 | $0.00 | 17,096 | $0.00 | 17,096 |
Ratcliffe Liam | Award | Jun 09, 2026 | $0.00 | 17,096 | $0.00 | 17,096 |
Ambrose Allison General Counsel | Sell | Mar 16, 2026 | $4,412.75 | 475 | $9.29 | 16,525 |
Sutherland Everett Rand Chief Executive Officer | Sell | Mar 16, 2026 | $19,443.97 | 2,093 | $9.29 | 72,907 |
GRAY MICHAEL CFO and COO | Sell | Mar 16, 2026 | $7,915.08 | 852 | $9.29 | 29,648 |
Houghton Adam Chief Business Officer | Sell | Mar 16, 2026 | $6,493.71 | 699 | $9.29 | 24,301 |
Sutherland Everett Rand Chief Executive Officer | Award | Jan 02, 2026 | $0.00 | 225,000 | $0.00 | 225,000 |
GRAY MICHAEL CFO and COO | Award | Jan 02, 2026 | $0.00 | 91,500 | $0.00 | 91,500 |
Ambrose Allison General Counsel | Award | Jan 02, 2026 | $0.00 | 51,000 | $0.00 | 51,000 |
Houghton Adam Chief Business Officer | Award | Jan 02, 2026 | $0.00 | 75,000 | $0.00 | 75,000 |
Sutherland Everett Rand Chief Executive Officer | Award | Jan 02, 2026 | $0.00 | 75,000 | $0.00 | 75,000 |
GRAY MICHAEL CFO and COO | Award | Jan 02, 2026 | $0.00 | 30,500 | $0.00 | 30,500 |
Ambrose Allison General Counsel | Award | Jan 02, 2026 | $0.00 | 17,000 | $0.00 | 17,000 |
Houghton Adam Chief Business Officer | Award | Jan 02, 2026 | $0.00 | 25,000 | $0.00 | 25,000 |
Deykin Aaron Chief Medical Officer | Award | Jan 02, 2026 | $0.00 | 96,000 | $0.00 | 96,000 |
Deykin Aaron Chief Medical Officer | Award | Jan 02, 2026 | $0.00 | 32,000 | $0.00 | 33,581 |
Beckman Daniella | Award | Jun 10, 2025 | $0.00 | 17,096 | $0.00 | 17,096 |
GRAY MICHAEL CFO and COO | Award | Feb 06, 2025 | $0.00 | 195,000 | $0.00 | 195,000 |
Ambrose Allison General Counsel | Award | Feb 06, 2025 | $0.00 | 25,000 | $0.00 | 25,000 |