UPB
UPSTREAM BIO (UPB)
NASDAQ
$6.33+$0.03 (+0.48%)
Price as of Jun 23, 2026 3:15 PM EDT
  • $342.8M
    Market Cap
  • -41.23%
    1-Year Change
  • Biotechnology
    Industry

Top Holders

Institutional
Mutual Funds
Holder
Ownership %
Shares Held
Change (Shares, %)
Report Date
FMR LLC
14.89%
8.1M
+583,361 (+7.20%)
Mar 31, 2026
ORBIMED ADVISORS LLC
10.46%
5.7M
0 (0.00%)
Mar 31, 2026
BLACKROCK, INC.
6.19%
3.4M
+26,185 (+0.78%)
Mar 31, 2026
NORGES BANK
5.30%
2.9M
+2.9M (+100.00%)
Dec 31, 2025
DECHENG CAPITAL LLC
5.01%
2.7M
-418,210 (-15.35%)
Mar 31, 2026
ENAVATE SCIENCES GP, LLC
4.52%
2.5M
0 (0.00%)
Mar 31, 2026
VANGUARD GROUP INC
4.39%
2.4M
-54,112 (-2.27%)
Dec 31, 2025

Current Ownership Distribution

  • Institutions230.5M (96.17%)
  • Mutual Funds8.9M (3.72%)
  • Insiders275,029 (0.11%)
  • Other0 (0.00%)

Insider Transactions

  • 0.11% (275,029)
    Current InsiderOwnership (%, shares)
  • 0
    Number of InsiderBuying (last 12 months)
  • $0.00
    Amount of InsiderBuying (last 12 months)
  • 5
    Number of InsiderSelling (last 12 months)
  • $2.3M
    Amount of InsiderSelling (last 12 months)
Insider Name & Title
Type
Date
Transaction Value
Shares
Share Price
Shares After Transactions
Ambrose Allison
General Counsel
Sell
Jun 16, 2026
$2,909.70
477
$6.10
16,048
Sutherland Everett Rand
Chief Executive Officer
Sell
Jun 16, 2026
$12,779.50
2,095
$6.10
70,812
Deykin Aaron
Chief Medical Officer
Sell
Jun 16, 2026
$5,459.50
895
$6.10
33,197
Houghton Adam
Chief Business Officer
Sell
Jun 16, 2026
$4,270.00
700
$6.10
23,601
GRAY MICHAEL
CFO and COO
Sell
Jun 16, 2026
$5,203.30
853
$6.10
28,795
Renaud Ronald C JR
Award
Jun 09, 2026
$0.00
17,096
$0.00
17,096
Beckman Daniella
Award
Jun 09, 2026
$0.00
17,096
$0.00
17,096
Fleming Harold Edward
Award
Jun 09, 2026
$0.00
17,096
$0.00
17,096
Ruddy Marcella K.
Award
Jun 09, 2026
$0.00
17,096
$0.00
17,096
Ratcliffe Liam
Award
Jun 09, 2026
$0.00
17,096
$0.00
17,096
Ambrose Allison
General Counsel
Sell
Mar 16, 2026
$4,412.75
475
$9.29
16,525
Sutherland Everett Rand
Chief Executive Officer
Sell
Mar 16, 2026
$19,443.97
2,093
$9.29
72,907
GRAY MICHAEL
CFO and COO
Sell
Mar 16, 2026
$7,915.08
852
$9.29
29,648
Houghton Adam
Chief Business Officer
Sell
Mar 16, 2026
$6,493.71
699
$9.29
24,301
Sutherland Everett Rand
Chief Executive Officer
Award
Jan 02, 2026
$0.00
225,000
$0.00
225,000
GRAY MICHAEL
CFO and COO
Award
Jan 02, 2026
$0.00
91,500
$0.00
91,500
Ambrose Allison
General Counsel
Award
Jan 02, 2026
$0.00
51,000
$0.00
51,000
Houghton Adam
Chief Business Officer
Award
Jan 02, 2026
$0.00
75,000
$0.00
75,000
Sutherland Everett Rand
Chief Executive Officer
Award
Jan 02, 2026
$0.00
75,000
$0.00
75,000
GRAY MICHAEL
CFO and COO
Award
Jan 02, 2026
$0.00
30,500
$0.00
30,500
Ambrose Allison
General Counsel
Award
Jan 02, 2026
$0.00
17,000
$0.00
17,000
Houghton Adam
Chief Business Officer
Award
Jan 02, 2026
$0.00
25,000
$0.00
25,000
Deykin Aaron
Chief Medical Officer
Award
Jan 02, 2026
$0.00
96,000
$0.00
96,000
Deykin Aaron
Chief Medical Officer
Award
Jan 02, 2026
$0.00
32,000
$0.00
33,581
Beckman Daniella
Award
Jun 10, 2025
$0.00
17,096
$0.00
17,096
GRAY MICHAEL
CFO and COO
Award
Feb 06, 2025
$0.00
195,000
$0.00
195,000
Ambrose Allison
General Counsel
Award
Feb 06, 2025
$0.00
25,000
$0.00
25,000
Sutherland Everett Rand
Chief Executive Officer
Award
Feb 06, 2025
$0.00
500,000
$0.00
500,000
Deykin Aaron
Chief Medical Officer
Award
Feb 06, 2025
$0.00
165,000
$0.00
165,000
Houghton Adam
Chief Business Officer
Award
Feb 06, 2025
$0.00
140,000
$0.00
140,000