• 66.72%
    1-Year Change

Top Holdings

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Company

Weight %

  • MODERNA
    MRNA (MODERNA)
    2.87%
  • TWIST BIOSCIENCE
    TWST (TWIST BIOSCIENCE)
    1.81%
  • Halozyme Therape
    HALO (Halozyme Therape)
    1.47%
  • Natera
    NTRA (Natera)
    1.46%
  • KYMERA THERAP
    KYMR (KYMERA THERAP)
    1.44%
  • TRAVERE THERAPET
    TVTX (TRAVERE THERAPET)
    1.40%
  • ROIVANT SCIENCES
    ROIV (ROIVANT SCIENCES)
    1.39%
  • ORUKA THERA
    ORKA (ORUKA THERA)
    1.38%
  • R
    RVMD (REVOLUTION MEDIC)
    1.36%
  • PRAXIS PRECIS
    PRAX (PRAXIS PRECIS)
    1.36%
  • Insmed
    INSM (Insmed)
    1.34%
  • Protagonist Ther
    PTGX (Protagonist Ther)
    1.33%
  • DIANTHUS
    DNTH (DIANTHUS)
    1.31%
  • Regeneron Pharma
    REGN (Regeneron Pharma)
    1.27%
  • CG ONCOLOGY
    CGON (CG ONCOLOGY)
    1.27%
TradeSmith Loading

Statistics

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Day Range
$156.13
$159.66
$156.20
1-Year Range
$93.43
$169.55
$156.20
Latest Close$156.20
Change
-$0.62 (-0.40%)
Volume8,413,894
Inception Date01/31/2006
Assets Under Management10.6B
Expense Ratio0.35%

Information as of 09/11/2026

Performers

Best Performers
Worst Performers

  • TYRA

    TYRA BIOSCIS

    $22.03+14.80%

  • MYGN

    Myriad Genetics

    $3.42+9.94%

  • CABA

    CABALETTA BIO

    $2.73+9.16%

  • CLDX

    CELLDEX THERAPTC

    $36.90+7.72%

  • IOVA

    IOVANCE BTHRPTCS

    $8.60+7.56%

  • CAPR

    CAPRICOR THERAP

    $8.37+6.33%

  • RXRX

    RECURSN PHARMA-A

    $3.20+5.94%

  • SMMT

    SUMMIT THERAP

    $17.55+5.93%

  • TWST

    TWIST BIOSCIENCE

    $127.22+5.80%

  • ORIC

    ORIC PHARMA

    $12.04+5.56%