IONS
Ionis Pharmaceut (IONS)
NASDAQ
$75.98+$0.08 (+0.11%)
Price as of Jun 23, 2026 4:15 PM EDT
  • $12.5B
    Market Cap
  • 101.46%
    1-Year Change
  • Biotechnology
    Industry

Key Performance

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  • Earnings Score: 27
  • Momentum Score: 72
  • True Yield: N/A
  • Financial Health Score: 79
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Latest Research & News

Protein Synthesis Research Market to Reach $42.8 Billion by 2031, Driven by Surging CGT Investment

The global protein synthesis research market is experiencing accelerating growth driven by increased investment in cell and gene therapy research, rising chronic disease prevalence, and expanding healthcare budgets. North America leads with 42.8% market share, while Asia-Pacific infrastructure expansion presents significant growth opportunities. Key market drivers include strong late-stage therapy pipelines and government support through initiatives like the CHIPS and Science Act.

05/18/2026, 2:33 PM • GlobeNewswire

Oligonucleotides Clinical Trial Drug Development Pipeline Expands with Contributions from 200+ Key Companies | DelveInsight

The oligonucleotides clinical trial landscape is expanding rapidly with 200+ companies developing 600+ pipeline drugs. Major players like Novartis, Alnylam Pharmaceuticals, Amgen, and WaVe Life Sciences are advancing promising therapies across various clinical stages. Approximately 20+ oligonucleotides are in late-stage development while 150+ are in mid and early stages. Recent developments include SanegeneBio's $110M Series B funding, FDA approvals for multiple orphan drug designations, and several companies advancing Phase II and Phase III trials.

05/14/2026, 1:00 PM • GlobeNewswire

Why Is Biogen Stock Falling Thursday?

Biogen stock fell 4.97% after reporting Phase 2 results for its Alzheimer's drug diranersen, which missed its primary endpoint but showed cognitive benefits and tau biomarker reductions across all doses. The company plans to advance the therapy to registrational development. Separately, Biogen completed its acquisition of Apellis Pharmaceuticals, adding two commercial drugs worth $689 million in 2025 revenue.

05/14/2026, 11:57 AM • Benzinga

GSK Targets China's Hepatitis B Market Through New Deal

GSK entered an exclusive strategic collaboration with Sino Biopharmaceutical to accelerate bepirovirsen, an investigational hepatitis B treatment, in mainland China. The drug is under priority regulatory review in China and showed positive Phase 3 trial data. GSK will retain marketing authorization and regulatory responsibility while CTTQ handles distribution and promotional activities. Additionally, GSK announced the final tranche of its £2 billion share repurchase program.

05/11/2026, 12:03 PM • Benzinga

Complement Inhibitors Market Outlook Remains Strong During the Forecast Period (2026–2036) with Increasing Adoption of C5 and C3 Targeted Drugs | DelveInsight

The complement inhibitors market is projected to experience strong growth through 2036, driven by rising prevalence of complement-mediated diseases, increased R&D efforts, and approval of new therapeutic agents. The US represents the largest market, with IgAN showing approximately 135,000 diagnosed prevalent cases. Key emerging therapies from major pharmaceutical companies are expected to expand treatment options across multiple indications including PNH, aHUS, CIDP, and IgAN.

04/30/2026, 1:00 PM • GlobeNewswire

IgA Nephropathy Market Forecast to 2036: Novel Therapies and Key Growth Drivers Fuel Expansion | DelveInsight

The IgA Nephropathy (IgAN) market is projected to grow at 18.6% CAGR through 2036, driven by rising disease prevalence, improved diagnostics, and a robust pipeline of novel immunotherapies. The market was valued at $1.5 billion in 2025, with recent FDA approvals including VOYXACT and multiple late-stage candidates from major pharmaceutical companies expected to reshape disease management.

04/29/2026, 1:00 PM • GlobeNewswire

Polycythemia Vera Market Set for Transformation: Key 9 Companies Expected to Enter by 2036 | DelveInsight

The polycythemia vera market is expected to expand significantly by 2036, growing at 8.9% CAGR from a 2025 valuation of approximately USD 2 billion. Nine major pharmaceutical companies are advancing next-generation therapies in various clinical development stages, with rusfertide from Protagonist Therapeutics and Takeda expected to be the first new entrant to market this year, potentially reshaping the treatment paradigm beyond current standard therapies like JAKAFI, BESREMi, and PEGASYS.

04/22/2026, 1:00 PM • GlobeNewswire

Praxis Precision Medicines Announces Positive Results from the EMBRAVE Part A Trial of Elsunersen in Patients with SCN2A Early-Onset Developmental and Epileptic Encephalopathy

Praxis Precision Medicines announced positive Phase 1/2 trial results for elsunersen (PRAX-222), an antisense oligonucleotide treatment for SCN2A developmental and epileptic encephalopathy. The drug demonstrated a 77% placebo-adjusted seizure reduction, with 71% of treated patients achieving >50% seizure reduction. All elsunersen-treated patients showed improvements in sleep, motor function, and attention, with no serious adverse events reported.

04/06/2026, 8:00 AM • GlobeNewswire

Ionis Pharmaceuticals Repriced Drug Ahead Of Key FDA Decision Signals Push Into Larger Market

Ionis Pharmaceuticals announced a significant price reduction for its triglyceride-lowering drug Tryngolza (olezarsen) from $595,000 to $40,000 annually, effective April 1. The repricing positions the therapy competitively ahead of an expected FDA decision on label expansion into severe hypertriglyceridemia (sHTG) by June 30. Analysts view the move positively as it aligns with payer contracting cycles and could drive substantial revenue upside, with peak sales projections potentially exceeding $2 billion.

03/26/2026, 1:47 PM • Benzinga

When Insider Selling Is a Good Thing: 2 Stocks to Watch

The article examines two stocks experiencing insider selling but maintaining bullish long-term outlooks. Waste Management insiders sold ~$25M after hitting all-time highs, but institutional accumulation and growing dividends support the outlook. Ionis Pharmaceuticals faces heavier insider and institutional selling, though analysts see 25% upside driven by Olezarsen's commercial ramp. Both stocks have pulled back from early 2026 highs, creating potential entry points.

03/24/2026, 3:07 PM • Investing

When Insider Selling Is a Good Thing: 2 Stocks to Watch

The article examines insider selling at Waste Management and Ionis Pharmaceuticals, arguing that profit-taking by insiders at these stocks presents buying opportunities. Waste Management benefits from institutional accumulation, strong dividend growth prospects, and analyst support despite insider sales. Ionis Pharmaceuticals faces heavier selling pressure but analysts project 25% upside driven by commercial growth of its drug Olezarsen and a bullish long-term earnings outlook.

03/24/2026, 10:24 AM • Investing

Biotech Stock Up 372% Gets Sold as New Pick Rises 40% in 2026

Boone Capital Management liquidated its entire $13.57 million stake in Cogent Biosciences (945,042 shares) in Q4 2026, despite the stock surging 372% over the past year. The fund reallocated capital to earlier-stage biotech opportunities like TYRA, which has gained 40% in 2026, suggesting a strategic shift toward higher-risk, higher-upside clinical-stage investments.

03/20/2026, 12:07 PM • The Motley Fool

Global Amyotrophic Lateral Sclerosis Therapeutics Market Size/Share Worth USD 1964 Million by 2035 at 11.5% CAGR: Custom Market Insights (Analysis, Outlook, Leaders, Report, Trends, Forecast, Segmentation, Growth Rate, Value, SWOT Analysis)

The global ALS therapeutics market is valued at USD 812 million in 2024 and is projected to reach USD 1,964 million by 2035, growing at an 11.5% CAGR. Growth is driven by innovations in genetic therapies, gene-silencing technologies, improved diagnostics, and increased disease awareness. Key players include Biogen, Ionis Pharmaceuticals, Amylyx Pharmaceuticals, and others developing disease-modifying treatments.

02/19/2026, 3:30 AM • GlobeNewswire

Amyloidosis Therapeutic Market to Worth Over US$ 6.37 Billion by 2033 | Astute Analytica

The global amyloidosis therapeutics market is experiencing strong growth, valued at $2.95 billion in 2024 and expected to reach $6.37 billion by 2033 with a 9.20% CAGR. Growth is driven by accelerating ATTR cardiomyopathy diagnosis through imaging technologies, rapid uptake of disease-modifying therapies in North America, and expanded reimbursement in emerging markets like China and Brazil. Five core compounds dominate the market, with chemotherapy remaining the cost-effective backbone for AL amyloidosis treatment.

01/21/2026, 10:54 AM • GlobeNewswire

GSK/Ionis Partnered Investigational Drug Shows Strong Results In Large Hepatitis B Studies

GSK and Ionis Pharmaceuticals announced positive Phase 3 trial results for bepirovirsen, an investigational antisense oligonucleotide for chronic hepatitis B. The B-Well 1 and B-Well 2 studies, involving over 1,800 patients, met their primary endpoint with statistically significant functional cure rates. If approved, bepirovirsen could become the first finite, six-month therapeutic option for CHB. Regulatory submissions are planned for Q1 2026.

01/07/2026, 11:48 AM • Benzinga

Peers

Statistics

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Day Range
$74.12
$76.56
$75.89
1-Year Range
$37.67
$86.50
$75.89
Latest Close$75.89
Change
+$1.77 (+2.33%)
Volume1,956,126
Market Cap$12.5B
Shares Outstanding165.3M
P/E (TTM)-37.67
Diluted EPS (TTM)-$2.01
Enterprise Value$13.6B

Information as of 06/22/2026

Company Profile

IONIS PHARMACEUTICALS INC
IONIS PHARMACEUTICALS INC
https://www.ionis.com
$12.5B
Market Cap
-$327.0M
Net Income
Sector: Healthcare
Industry: Biotechnology
2855 Gazelle Court, Carlsbad, CA, United States, 92010
760 931 9200

Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; DAWNZERA for prophylaxis to prevent attacks of hereditary angioedema in adults; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult patients with spinal muscular atrophy (SMA). It also provides QALSODY for the treatment of Amyotrophic Lateral Sclerosis (ALS); TEGSEDI for the treatment of ATTRv-PN in adults; and WAYLIVRA for treatment for FCS and familial partial lipodystrophy. It also develops products under Phase 3 clinical trials, such as Olezarsen for patients with hypertriglyceridemia (SHTG) and cardiovascular disease (CVD); and Zilganerse, a potential treatment for people with genetically confirmed Alexander disease, as well as ION582 which is in Phase 3 clinical trial for the potential treatment of AS, a rare genetic neurological disease. In addition, the company develops Eplontersen to degrade mutant and wild-type TTR mRNA through binding to the TTR mRNA; Pelacarsen to inhibit the production of apolipoprotein(a) in the liver to offer a direct approach for reducing lipoprotein(a); Bepirovirsen to inhibit the production of viral proteins associated with hepatitis B virus; Sefaxersen to reduce the production of complement factor B and lower activation of the alternative complement pathway; and Ulefnersen to reduce the production of the fused in sarcoma, as well as other mid-stage pipeline investigational medicines. It has a strategic collaboration with Biogen for the treatment of neurological disorders; and collaboration and license agreement with GSK, AstraZeneca, Novartis, and Roche, as well as with Metagenomi. The company was incorporated in 1989 and is headquartered in Carlsbad, California.

Key Executives

  • Brett Monia
  • Elizabeth L. Hougen
  • Richard S. Geary
  • Brian Birchler
  • Eric E. Swayze

Current Ownership Distribution

  • Institutions2.7B (61.62%)
  • Mutual Funds1.7B (38.34%)
  • Insiders1.6M (0.04%)
  • Other0 (0.00%)